跳转到内容

二甲双胍

出自维基百科,自由个百科全书

二甲双胍(英语:Metformin)是治疗2型糖尿病个一线药物,特别是针对超重患者。本品属于口服药物,通常呒没明显副作用,常见副作用包含腹泻、恶心、腹痛咾啥,造成低血糖个机会不大。常见商品名格华止、库鲁化(Glucophage)。

本品也好用于治疗多囊卵巢综合症,一眼动物实验还发现渠交关别样用场。

  • 完全逆转疼痛产生个认知障碍。[1]
  • 作为AMPK激动剂缓解尼古丁戒断反应以协助戒烟。[2]
  • 作为AMPK激动剂让抗拒细胞凋亡个肌成纤维细胞增多以逆转肺纤维化。[3]
  • 通过提高细胞核里Nrf2转录因子个水平来提高谷胱甘肽过氧化物酶7表达以延缓衰老。[4]
  • 通过抑制肝癌细胞对己糖激酶抑制(饿杀肝癌细胞)个适应性反应(增强葡萄糖氧化磷酸化)来增加细胞死亡並抑制肿瘤增生。[5]

文献

[编辑]
  1. ↑ Neuropathic Pain Creates an Enduring Prefrontal Cortex Dysfunction Corrected by the Type II Diabetic Drug Metformin But Not by Gabapentin
  2. ↑ Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal
  3. ↑ Metformin reverses established lung fibrosis in a bleomycin model
  4. ↑ Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7
  5. ↑ Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin